Иосиф Алексaндрович Бродский,          в  прозаическом  переводе     и     как поэтический автоэпиграф

[Joseph Aleksandrovich Brodsky,             translated     prosaically     and     as a poetic autobioepigraph]  by

EDUCATION

B.S./M.Sc. in Physics/Radiophysics from Alma Mater of numerous Nobelists in every Field, Saint Petersburg State University, where Mendeleev, Popov, Markov, et al Chemists, Physicists, Mathematicians et al Scientists, Literators, and Statesmen have achieved Breakthroughs Changing the World. There the 'A'-Student Babenko has underachieved 'B' in Statistical Thermodynamics et Nonlinear Acoustics after colliding with Илона М. Смагаринская walking like dancing on Italian hills in the subsequently presidentially tramped SPbSU runway  and spending his energy on bonding with the Красавица (Rare Beauty, see below) rather than on exciting his examiners, presiding on the top level of the top Faculty of Radiophysics in the Universe. But after producing with her the next-generation Krasavitsa (see later), the Gen X Ανδρέας has presented his scientific findings about non-classified effects of non-ionizing radiations, including mm-radio-waves and ultra-short acoustic waves, twhich he's made while experimenting in a Biophysical Research Lab at the legendary Military Medical Academy (see more about the Organization there) in then Leningrad (see "Responses of Complex Biological Systems to Application of Low-Intensity 'Millimetric' Waves". G.N. Chernyakov, V.L. Korochkin, A.P. Babenko, E.V. Bigday, in: 'Millimetric' Waves in Medicine and Biology. Moscow, 1989, Edited by N.D. Devyatkov, pp.140-167 [in Russian], A. P. Babenko, G. N. Chernyakov, 1992, in the PubMed accessible journal, and subsequent related Applications and Patents copied not only by Googlers and Baiduists here, here, here, here and there), defended his A-grade Thesis EPR spectroscopy analysis of blood plasma from men in malady (not le malade  but a common disease he conquered later) and graduated with Hex#90000 Magister Diploma G1 N397845 in 1993.

M.D. with egregia cum laude (Crimson Diploma with Gold Medal HB N789251) from S. M. Kirov Military Medical (formerly Imperial Medico-Surgical) Academy, a.k.a. MMA, VMA, VMedA, where the most promising applicants, then young not-too-gentle men only, were selected at a 5%-rate by the Scientific Knowledge, Health, Physical & Psychological Strength Examining Federal Commission - not like any of Super-Profiting Western Medical  School Admission Offices auctioning Early Admission tickets for the next-generation Western elite paying for playing under supervision of Secret Servicemen - for a brutal 6-day-a-week-6-year Medical Training Program to learn Physiology and Pharmacology at Sechenov and Pavlov Departments, Biological & Medical Physics at Petrov Department, Diagnostics & Therapy in Botkin Hospital, Topographic Anatomy & Operative Surgery in Pirogov Institute, Pathology at Anichkov Department, Psychiatry and Conditioning (translated as Cognitive Behavior Therapy) in Bekhterev Clinic, Hematology, Immunology & Regeneration in the CIA-copied Arinkin and Maksimov Clinical Research Centers, Parasitology and Epidemiology of Infectious Diseases in then the USSR leading Pavlovsky Institute, and about 50 more Disciplines and Specialties, including Military Virology, Bacteriology, Toxicology, Radiobiology and the world's #1 Space Medicine, in elite Institutions for Advanced Biomedical Research. Medical Cadet Babenko has spent enough time at the Academy Kitchen and Dining Halls to pass the test in gentlemen's favorite Facultative Course Nutrition and Aæthetics of Feeding, taught by a fearless and skillful CAI). Андрей Петрович codenamed BOA (Boa of Ἀσκληπιός) has also spent quite a time at the Academy Training 'Farm' surrounded by swamps, where he, moving аки тать в нощи, with a still classified number of poods of special medical equipment and other tools attached to his camouflaged back-pack, tæsted Vaccinium angustifolium et Artemisia annua (Artemisinin was prized in the West 25+ yrs later) while shooting useless females from the deadliest swamp near Krasnoye Selo with a laser pointer during the White Nights, not under garage lamp lights, as it was staged in another 25+-yrs-later SDI-funded Intellectual Ventures movie. Upon completion of his Stagerovka (brief Residenture) at the Best Army Base in Beautiful Carelia and the Best Hospital in Hansom Vyborg, the NorthWest Region, the never-filmed, just B&W Photo-documented, Doctor and Officer "AB 008" took his Hippocratic Oath under the prettiest Hygieia and abluted the rarest Academic Romb in the purest Caucasian Borjomi while banqueting with other Golden Boys, none of whom has however received his favorite and the most prestigious Order, in Granovitaya and Georgievsky Palaces, as both places ran out of Mendeleev-invented antifreeze needed to mix ex tempore w/o shaking the most celebrated binary celebratory drink much more appropriate than just the Aqua from then The Soviet Republic of Georgia, discovered by Imperial Russian Military, soon after The Perestroishik General, a.k.a. Loser Gorbachev has ordered "No more alcohol in Kremlin", in 1988. [WARNING: Readers of this Memoir who do not smile at this point should stop doing so or seek a doctor from the VMA's Bekhterev Clinic!]

Ph.D. in Medical Sciences / Biophysics from VMedA - Interdepartmental Laboratory of Cellular Physiology and Biophysics (later the CPB Lab at INFRAN), Russian(then USSR) Academies of Sciences and Medical Sciences (RAS/RAMS), and Ministry of Defence's Medical Department. Dr. A. P. Babenko has defended his "Principles of Cardiac Potassium Channels' Responses to Stimuli of Certain Physico-Chemical Nature" (Thesis Adviser - Corresponding Member of RAMS, Head of the CPB at Pavlov Institute for Physiology RAS, former Head of the Department of Medical & Biological Physics of VMA and then the Academy's Vice-President for Science and Education, General-Major of Military Medical Service, Honorary Member of the National Naval Medical Center in Bethesda and Wilford Hall Medical Center in San-Antonio in the U.S., the past SPbSTU's Faculty of Medical Physics and Bioengineering Dean, and Chairman of VMedA's Department of Normal Physiology, Professor of Biophysics, V. O. Samoilov) and received his Medical Scientist (Hex#722f37) Doctoral Diploma N055286 in 1992, becoming the youngest interdisciplinary MSc/MD/PhD Scientist and non-Corporate but Commanding Medical Officer [Военврач] who refused to betray his Adviser & Alma Mater to make money with DTh/MD/PhD.

 

"What for is your 6+6+4-year Advanced Education money can't buy in the States where some with just a high school diploma become the richest men?!" - One American Interviewer

"Learning is a treasure that will follow its owner everywhere." - Chinese Proverb

"There is a cult of ignorance in the United States, and there has always been. The strain of anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that "my ignorance is just as good as your knowledge." - Isaac Azimov

"Any existing distinction between the wise and the stupid... comes down to a matter of education." - 福澤 諭吉 Fukuzawa Yukichi

"Only the educated are free." - Ἐπίκτητος [Epictetus]

"Democracy cannot succeed unless those who express their choice are prepared to choose wisely. The real safeguard of democracy, therefore, is education." - Franklin D. Roosevelt, praised by another wise Statesman

“Modern cynics and skeptics see no harm in paying those to whom they entrust the minds of their children a smaller wage than is paid to those to whom they entrust the care of their plumbing.” - John F. Kennedy, shortly before he was assassinated

"The function of education is to teach one to think intensively and to think critically. Intelligence plus character - that is the goal of true education. Martin Luther King, Jr., shortly before he was assassinated

"Education is the most powerful weapon which you can use to change the world." - Nelson Mandela, a unique black President who changed the world to be a better place for millions of exploited and yet died naturally

"Focusing your life solely on making a buck shows a poverty of ambition. It asks too little of yourself. And it will leave you unfulfilled." - Barack Hussein Obama, a speech reader, who, after taking the 'Dynamite Man' Peace Pri$e, has enabled I$, CIA Drones and U.S. Missiles threatening Russia, Coup d'état in Ukraine, et al Operation$ of the Military-Industrial-Financial Oligarchy-serving Deep $tate, not for a buck from each of them

"What is the purpose of industrial education? To fill the young of the species with knowledge and awaken their intelligence? Nothing could be further from the truth. The aim is simply to reduce as many individuals as possible to the same safe level, to breed and train a standardized citizenry, to put down dissent and originality. That is its aim in the United States." – Henry Louis Mencken

"Getting a job is not the purpose of school." - Terry Heick

"Education is not preparation for life; education is life itself." - John Dewey

"Once you stop learning you start dying" - Albert Einstein

"Век живи - век учись [Live for a century - learn for a century]" - Russian Proverb

ADVANCED POSTDOCTORAL TRAINING В ЧУЖЕСТРАНЬЕ (IN THEN €-FREE WESTERN EUROPE AND PRE-'IRAQI FREEDOM' U$A)

Upon recommendation of the Full Member of RAMS et al Academia Professor V. A. Tkachuk, who headed the Faculty of Fundamental Medicine at Lomonosov Moscow State University (MSU) plus a few top Institutes for Biomedical Research, Dr. Babenko, M.Sc., M.D., Ph.D. applied for, and won, MESR International Fellowship at the National Institute of Health and Medical Research (INSERM) Unit of Cardiovascular Physiopathology - moving from Paris Sud to Southern France to co-occupy the new research building in Montpellier with the Unit for Studies of Diabetes led by Dr. Bataille then working on endosulfine pepties - under the direction of Member of Academia Europaea's Physiology and Neuroscience Section, Dr. G. Vassort (now Directeur Emeritus). Using a combination of advanced electrophysiological techniques, micro-spectrofluorometry methods, micro-injection, and selective blockers and agonists, Drs. Babenko and Vassort co-investigated Regulation and pharmacological modulation of ATP-sensitive potassium and ATP-gated calcium-permeable cation channels under pathological conditions. The two Med Scientists became colleagues and friends forever remembering these exciting times, in 1995-6, while they were working and playing in the magestic hometown of the oldest Faculty de Medecnie where Physiologistes et Médecins have discovered the hypoglycemic action of KATP-inhibiting sulfonamides, changing for good lives of billions with type 2 Diabetes, without talking much about and without getting any Prize for that truly seminal contribution to Physiology and Medicine.

Next, in 1996, instead of enjoying tenure at Pavlov First St. Petersburg State Medical University and INFRAN, Dr. Babenko decided to accept the three-year JDRF International Fellowship in the Laboratory of the 1996' DeBakey Prize Nominee, Prof. of Cell Biology J. Bryan at the Baylor College of Medicine's Top Department under "the father of molecular endocrinology", BCM MCB in Houston, TX, to pioneer the primary structure-function analyses of "metabolic sensors", including normal and mutant cardiovascular and neuroendocrine ABCC8,7/KCNJ11,8-coded, [ATP]/[MgADP]-sensing, selectively potassium-conducting, tetra-heterodimeric KATP complexes of inward rectifiers, K_IR6.x, and sulfonylurea receptors, SURx, cloned separately by Seino and Bryan groups, and famously reunited [reconstituted by coexpression generating KATP currents, IKATP] by the two teams in Chiba and Houston upon the brilliant suggestion of Daniel Cook, then Professor of Physiology and Biophysics at the University of Washington in Seattle. Working in the America's top Department of the World's Biggest Medical Center's School of Medicine gave Dr. Babenko a super-excitement, a superb satisfaction, and a superior experience in leading a discovery process even in a pseudo-egalitarian atmosphere of an ultra-conservative Private Medical School in the uniformly Red State with a terrible climate.

POSITIONS AND RESEARCH PROGRAMS (IN THE ANTI-CHRONOLOGICAL ORDER LIKED BY LINKEDIN BUT NOT ALL OTHERS:)

Principal Scientist/Principal Investigator/Head of the Private Nonprofit Research Laboratory for Cellular and Molecular Electrophysiology, Biophysics and Pharmacology, Adjunct Research Professor of Molecular Physiology and Biophysics, affiliated with the formerly Pacific NorthWest Research Foundation/Diabetes Research Institute and Diabetes Endocrinology Research Center of the University of Washington in Seattle (UW). Since 2009. PI, the NIH Project ABCC8/KCNJ11 Mechanisms and Diabetes, focused on (SURx/Kir6.x)₄ in Pathophysiology and Personalized Treatment of Neonatal Diabetes, ND w/ Epilepsy and Developmental delay, DEND Syndrome, Maturity-Onset Diabetes of Young, MODY12 and 13, and Type 2 Diabetes, T2D. Directed the DoD/PNRF/PNRI-sponsored Pilot studies of mutant metabolic sensors altering neuronal excitability, initiated Private Nonprofit Research Investigations of Rare orphan transportochannelopathies, including syndromic hypertrichotic osteochondrodysplasia, cardiomegaly and hyperproliferative dysplasias, and offered international pro bono consulting. 2013-

Scientist at Pacific Northwest [once Diabetes] Research Institute - Affiliate Associate Professor of Physiology and Biophysics at the UW Diabetes Endocrinology Research Center. Co-PI, NIH R01 Studies of Sulfonylurea Receptors and K_ATP Channels. Using patch-clamping, photolabeling,  mutagenesis, and molecular dynamics simulation, established mechanisms of diabetogenic and epileptiformic KATP overactivity, determined the stoichiometry of Mg·nucleotide hyper-stimulation of ND-SUR based channels, and deduced the relative pathogenicity of mixed KATP in subjects with heterozygous mutations in KATP genes, thus answering all three longstanding questions in the field. 2007-9.

Assistant Professor of Molecular and Cellular Biology, Baylor College of Medicine (BCM), Houston, TX. PI, American Heart Association (AHA) National Scientist Development Program on Molecular Pharmacology of Cardiovascular KATP. Co-PI, NIDDK R01 Studies of Sulfonylurea Receptors and ATP-sensitive Potassium Channels. Analyzed structural determinants of gating in (SUR/K_IR6)₄ isoforms that link the metabolic status and electrical activity of insulin-secreting cells, neurons, striated myocytes and vascular smooth muscle cells. Defined TMD0-L0 of SUR as a "gatekeeper" that links the multi-drug-binding TMD1-NBD1-TMD2-NBD2 core of SUR with the K_IR6 pore and bidirectionally controls the open channel probability, P_O. Analyzed structure-activity relationships for SU and non-SU inhibitors of KATP variants and defined the bipartite nature of the pocket for these drugs, leading to re-grouping/classifying them as A-, B-, and A/B-site insulinotropes. In collaboration with Prof. P. Froguel and other European Medical Geneticists, discovetred multiple gain-of-P_O mutations that cause either Transient or Permanent ND with neurological abnormalities, and successfully switched their carriers from insulin pumps and life-long insulin injections to SUR1-specific sulfonylurea tablets, recommended by the World Health Organization (WHO) as an essential, tier 1, antidiabetic medicine. 2002-7.

 

Instructor of Molecular and Cellular Biology, BCM MCB. PI, AHA Beginning Grant-in-Aid Cytoplasmic Domains of Kir6.2, SUR2A, and Their Interaction in Gating and ATP-inhibition of Human Cardiac KATP. Co-Investigator, NIH R01 Structure of ATP-sensitive Potassium Channels. Revealed the primary structure-function relationships in K_IR6.1-based "K_NDP" and K_IR6.2-based "classic" KATP, using chimeric ABCCs, hybrid K_IRs, their concatemers, synthetic peptides, affinity photo-labeling, and single-channel recording. Delineated the SUR N-terminal part specifying dissimilar intrinsic P_O of classic KATP isoforms. Clarified specific functions of cytoplasmic domains of K_IR6.1(2) and nucleotide binding domains (NBD) 1 and 2 in nucleotide-binding sites (NBS)1/2 of ABCC8(9) in gating of KATP variants. Established effects of K_IR6 subunit composition and order on the conductivity and gating of hetero-octameric channels. Found 'hybrid' KATP in developing cardiomyocytes; defined pharmaco-topology of SUR1 and SUR2 variants. Identified the SU-binding locus and domains that recognize K⁺ channel openers. All that was achieved in 1999-2002 while Dr. Babenko was trapped in the transition state of Instructor, opposing the BCM Executives-supported Militaristic Bushism.

Senior Fellow of the Juvenile Diabetes Research Foundation International in Joseph Bryan Lab at BCM MCB, while on a long-term sabbatical from Pavlov First State Medical University and Institute of Physiology of RAS. Pioneered JDRF/NIH-funded Analyzes of structure vs activity in cloned pancreatic and extra-pancreatic KATP, using electrophysiological, biophysical and molecular biology methods. Originally reconstituted and fully characterized human sarcolemmal KATP (hu-sarco-KATP). Showed the role of regulatory SUR subunits in trafficking, spontaneous single-channel bursting, and nucleotide regulation of all K_IR6-based channels. Using innovative chimeric human ABCCs, engineered without introducing amino acid mutations, led the Glaxo Smith Kline-sponsored Analysis of functional pharmacotopology of human SUR1 vs SUR2 isoforms. 1996-9.

 

Visiting Investigator, INSERM U-390, Montpellier, FR, while on a sabbatical leave from I. P. Pavlov First State Medical University (ISPbGMU) and Institute of Physiology of RAS (INFRAN). Co-PI, INSERM-funded Collaborative Biomedical Research with Central and Eastern European Countries. Ended up the popular yet wrong theory on activation of ATP-inhibited weak inward rectifiers by GTP-binding proteins (G proteins). Uncovered the Mg·GTP-affected but G-protein-independent stimulation of isolated KATP, suggesting their intrinsic, CFTR-like, hydrolytic activity before any biochemical data suggesting the ATPase activity of any ABCC-coded protein. 1996.

 

Senior Scientist and Leader of Molecular Cardiology Group at the I. P. Pavlov State Medical University and Institute for Physiology RAS in Saint Petersburg (ISPbGMU and INFRAN). Fellow of the French Ministry of Higher Education and Research at INSERM Physiopathologie Cardiovasculaire. PI, Russian Foundation for Basic Research (RFBR) Program Molecular Mechanisms of Cardiac K_IRs Regulation Under Pathophysiological Conditions. Led the International Collaborative Project Purinergic Modulation of Cardiac ATP-sensitive K⁺ Channels Channels, supported by the Foundation for Medical Research, FMR, in France. Investigated effects of extracellular ATP and its analogs on sarcolemmal P_2X and background K⁺ currents. Revealed a new signaling pathway from P_2Y-purinoceptors to sarco-KATP. Discovered hybrid KATP in developing neonatal cardiomyocytes. 1994-6.

 

Scientist, Interdepartmental Laboratory for Cellular Physiology and Biophysics (ILCPB), a.k.a. 'Laboratory of Biophysics of Living Cell' at VMA, the Medical Department of MoD, and RAM/S. PI, Russian Foundation for Fundamental Investigations (later RFBR) Program Molecular Physiology of Metabolism-dependent Cardiac K⁺ Inwardly Rectifying Channels. Co-PI, Collaborative project with Institute of Cytology RAS Ion Channels in Osmotic Regulation, focused on voltage-gated K⁺ delayed rectifiers in human lymphocytes and stretch-activated Cl^- channels in dividing K562 and Jurkat cells during regulatory volume decrease (RVD) related to onco-invasiveness and cancer aggressiveness. 1993-4.

 

Junior Scientist, then called 'Junior Scientific Researcher', ILCPB. Combined advanced electrophysiological, biophysical and in situ live-cell microscopy methods to determine effects of microwaves, ultrasound and other, including DoD-relevant, physical and chemical factors on pacemaker cells. Investigated modulation of native cardiac strong inward rectifiers as well as ATP-inhibited and Na⁺-activated weakly inwardly rectifying potassium channels by non-ionizing radiation, heat and cold, non-permeate cations, changes in ionic strength, intra- vs. extracellular acidosis and alkalosis, and other common stimuli, at the single-channel kinetics level. Recorded K⁺ efflux dynamics in cardiocytes upon hypoxia. Identified KATP in human ventricular cells (in collaboration with then Professor and Chief of Kupriyanov Cardiovascular Surgery Clinic, later President of VMA, General-Colonel of Military-Medical Service, Laureate of the 96' Special International DeBakey Award, Director of Maksimov Stem Cell and Regeneration Center and Sechenov National Center for Thoracic and Cardiovascular Surgery in Moscow, Member of RAMS and eventually of its Presidium, Minister of Health and Medical Industry of the Russian Federation, et cetera, et cetera - an exemplary careerist of Criminal Eltsin's Times, whom then Lieutenant-Commander of Medical Service Babenko refused to continue working with after that Lieutenant-General of Medical Service and Doctor of Theology has tried to defame General-Major of Medical Service, the VMA's VP for Science and Education, V. O. Samoilov, and ~50 Professors and Department Heads of the Academy in order to gain an uncontrolled power and attempt 'commercialization', 'privatization', and, ultimately, sale of its Clinics, Laboratories and other assets. Dr. Babenko has built, in 1988, the USSR's first laboratory bringing together patch-clamp and fast ultra-resolution live-cell digital video-microscopy using advanced components developed at LOMO. The Junior Scientist has related KATP currents and Ca²⁺-dependent alteration in contractile apparatus of cardiomyocytes during anoxia or inhibition of oxydative phosphorylation or glycolysis. He critically reevaluated the popular adenosine hypothesis of sarco-KATP activation during ischaemia and discovered endopeptides increasing the probability of cardioprotective sarco-KATP opening (in cooperation with M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS and VMA-based V. Kh. Khavinson-directed Cytomed, later Neopharm, subsequently reorganized into the RAMS NW Branch-Integrated Institute of Bioregulation and Gerontology). 1988-92.

RESEARCH GRANT SUPPORT HISTORY (IN CHRONO=LOGICAL ORDER)

The Russian Foundation for Fundamental Investigations (later RFBR) Grant Molecular Physiology of Metabolism Dependent Cardiac K⁺ Inwardly Rectifying Channels, 1993-1994, Principal Investigator (PI).

RFBR Grant Molecular Mechanisms of Cardiac K_IRs Regulation under Pathophysiological Conditions, 1994-1996, PI.

The French MESR Grant Purinergic Modulation of Cardiac ATP-sensitive K⁺ Channels, 1995-1996, Investigator.

The French FMR Grant Analysis of Signaling Pathway from Purinoceptors to KATP Channels in Ischemic Ventricular Cardiomyocytes, 1996, Co-Investigator.

INSERM Grant for Collaborative Biomedical Research with Central and Eastern European Countries: Studies on Molecular Basis for Nucleotide Regulation of Sarcolemmal ATP-sensitive K⁺ channels, 1996, Co-PI.

JDRF International Grant Nucleotide-Binding Domains of Sulfonylurea Receptor 1 (SUR1) in Regulation of K_ATP Channels, 1997-1999, Investigator.

NIH R01 Structure of ATP-sensitive Potassium Channels, 1997-2001, Co-Investigator.

GSK Co-sponsored Analysis of structure-activity relationships in human ABCC8/KCNJ11-coded (SUR1/K_IR6.2)₄ pancreatic beta-cell KATP, 1997-1999, Co-Investigator.

AHA GIA Cytoplasmic domains of K_IR6.2, SUR2A, and their interaction in gating and ATP-inhibition of human cardiac K_ATP channels, 1999-2001, PI.

AHA SDG Molecular determinants and mechanisms of potassium channel openers action on human SUR2A/B-containing K_ATP channels, 2001-2004, PI.

NIH R01 Studies of Sulfonylurea Receptors and ATP-sensitive Potassium Channels, 2002-2007, Co-PI.

NIH R01 Studies of Sulfonylurea Receptors and K_ATP Channels, 2005-2009, Co-PI.

NIH R01 ABCC8/KCNJ11 Mechanisms and Diabetes, 2009-2012, PI.

DoD Grant 10305 - Pilot Study 5, 2011-2012, PI.

Pacific Northwest Research Foundation (PNRF) Grant for eXploratory Study 79, 2009-2013, PI.

Privately funded Preliminary Studies for High-Risk, High-Reward Research, conducted by PI since 2013.

TEACHING AND MENTORING EXPERIENCES (ALSO IN CHRONO=LOGICAL ORDER, PREFERRED BY CLASSICAL EDUCATORS)

Developed Electrophysiology and Membrane Biophysics Course at the VMA Department of Biological and Medical Physics, 1992.

 

Lectured twenty four MD students at the VMA Department of Biological and Medical Physics, 1993.

 

Co-advised two M.Sc. students from Departments of Biology and Physiology of Saint Petersburg State University during their Thesis Project research in the Interdepartmental Laboratory for Cell Physiology and Biophysics, 1993-4.

 

Created a multimedia Introduction to Ion Channels in Disease for MD/PhD Trainees at Saint Petersburg State Medical University, 1995.

 

Co-mentored one Ph.D. student from the Department of Molecular Physiology and Biophysics and one postdoctoral fellow from the Department of Molecular and Cellular Biology, BCM, 2000-6.

Trained one Postdoctoral Researcher in single-channel current analysis, in 2009, and mentored one PhD Research Scientist, in 2010-2, at Pacific NW Research Institute.

ACADEMIC HONORS AND AWARDS

• National AHA Career Development Award, 2001-2005

• Inclusion in the International Directory "2000 Outstanding Scientists of the 20^th Century" by International Biographical Center, Cambridge, UK, and in Directories of American Biographical Institute and "Who's Who" in Science, 2000 

• Fellowship from Juvenile Diabetes Research Foundation International, 1997-1999

• Travel Award from UNESCO and International Union for Applied Biophysics, 1996

• INSERM Award Action Specifique avec les Pays d'Europe Centrale et Orientale dans Domaine de la Recherche Biomedicale, 1996

• Award from Fondation pour la Recherche Medicale, 1996

• Fellowship from Ministere de l'Enseignement Supérieur et de la Recherche, 1995

• Outstanding Young Investigator Travelship from European Science Foundation, 1994

• International Science Foundation Travel Awards, 1993 and 1994

• Soros' Award for Excellence of a Young Scientist in Fundamental Research, 1993

• Gold Medal from VMA, the Ministry of Defence, 1988

• VMA Silver Key for Medical Student Research Project, 1988

• Academic I. P. Pavlov MD Scholarship, 1986-1988

• Valedictorian with Gold Medal from the USSR's Ministry of Education, which allowed Early Testing for Admission to VMA, 1982
  

• The Golden Key in a regional Chemistry Olympiad, Chekhov, Moscow region, 1982

• The "Golden Student" didn't get even a Bronze Pin at the All-Union Chemistry Olympiad, held in one of his mind-blowing auditoriums of the Lomonosov Moscow State University, in 1982.

SCIENTIFIC REVIEWING

AD HOC SCIENTIFIC RESEARCH FUNDING AGENCIES:

• National Institutes of Health
  

• National Science Foundation

• American Diabetes Association

• American Heart Association

• The Wellcome Trust

• British Heart Association

• Scottish Hospital Endowments Research Trust

• Russian Foundation for Fundamental Investigations 
  

AD HOC SCIENTIFIC JOURNALS:

• Journal of Clinical Investigations

• Proceedings of the National Academy of Sciences 
  

• Diabetes

• Circulation 

• Circulation Research

• FASEB Journal
  

• Journal of Clinical Endocrinology and Metabolism 

• Molecular Pharmacology

• Human Molecular Genetics
  

• Journal of Physiology (London) 

• Biophysical Journal 

• Journal of General Physiology 

• FEBS Letters 

• Journal of Molecular and Cellular Cardiology 

• Diabetologia

• Pediatric Diabetes

• British Journal of Pharmacology

• Nature Review Endocrinology
  

• Expert Opinion on Investigational Drugs

• Trends in Molecular Medicine (Cell Press)
  

• The Scientist prefers evaluating manuscripts for top disciplinary journals to reviewing papers for "broad auditorium" magazines, e.g. Nature, which long-term Impact Factor is lower than that of more specialized journals, e.g. Cell and The New England Journal of Medicine. While admiring Science (mostly for publishing Original Research Articles on cloning of SUR1 and of real, not fake "rat KATP" from OHSU, accepted by Nature, that has also published "promiscuous SUR1" and other "exciting" scientific fiction stories from the UK), the Scientist does not measure other Scientists' impact by the number of their papers accepted by Science's Editors admiring "Fashionable Science".

OTHER ACADEMIC ACTIVITIES, PROFESSIONAL SERVICE, AND LEADERSHIP EXPERIENCE

• Lieutenant (1988-90) and Lieutenant-Commander (1991-4) of Military Medical Service, The NW Region

• Scientific Secretary, The Problem Commission on General and Cell Physiology, The Russian Academy of Sciences, 1993-4

• Chairman, "Ion Channel Regulation" Symposium, Biophysical Society, 2003

• Chairman, "Potassium Inward Rectifiers" Symposium, Biophysical Society, 2004

• Member of Faculty Search Committee, Pacific Northwest Research Institute (PNRI), 2009

• Recruiter of Research Staff for PNRI, 2009-10

• Presenting PI at The Pacific Northwest Research Foundation's Board of Trustees Meetings, 2009-10

• Initiator of a special Fundraising Campaign that led to a non-governmental support of Babenko Lab at PNRI during The Great Recession, 2009-12

• Faculty Participant of Annual Fundraising Events for PNRF, 2009-13

• A pro bono consultant leading a Global Search of Rare Syndrome Probands, 2013-

MEMBERSHIP OF PROFESSIONAL SCIENTIFIC SOCIETIES, FOUNDATIONS AND ASSOCIATIONS 

• Biophysical Society, 1995 -

• Juvenile Diabetes Research Foundation International, 1999-

• American Diabetes Association, 2000

• American Heart Association, Basic Cardiovascular Science Council, 2001-

• American Society for Biochemistry and Molecular Biology, 2002 -

• American Physiological Society, 2002

• Dumped Research Organizations, Foundations and others Institutions spending increasingly on their executives while decreasingly on Academic Research.

INTERNATIONAL SCIENTIFIC MEETINGS ^*ATTENDED TO GIVE A LECTURE, TALK AT A WORKSHOP, OR PRESENT AT A SESSION

            2013    Annual Meeting of the Biophysical Society, Philadelphia, PA

            2012    Annual Meeting of the Biophysical Society, San Diego, CA

            2011    Annual Meeting of the Biophysical Society, Baltimore, MD

            2010    The 16^th World Congress of Basic and Clinical Pharmacology - WorldPharma2010, Focused                                Conference “Ion channelopathies: new windows on complex disease and therapy”,                                              Copenhagen, Denmark* 

            2010    Keystone Symposium on Diabetes, Whistler, British Columbia, Canada*           

            2010    The 3^rd FEBS Special Meeting on ABC Proteins: From Multidrug Resistance to Genetic                                        Diseases, Innsbruck, Austria*

            2010    The Annual Meeting of The Biophysical Society, San Francisco, CA

            2009    The Annual Meeting of The Biophysical Society, Boston, MA.

            2007    The Annual Meeting of The Biophysical Society, Baltimore, MD.

2006    The Annual Meeting of The Biophysical Society, Salt Lake City, UT.

2005    The Annual Meeting of The Biophysical Society, Baltimore, MD.

2004    The Gordon Research Conference on Ligand Recognition & Molecular Gating, Ventura, CA.

2004    The Annual Meeting of The Biophysical Society, Baltimore, MD*.

2003    The Annual Meeting of The Biophysical Society, San Francisco, CA*.

2002    The Gordon Research Conference on Ion Channels, Tilton School, NH.

2002    The Gordon Research Conference on Ligand Recognition and Molecular Gating, Il Ciocco,                    Italy.

2002    The Annual Meeting of The Biophysical Society, Boston, MA*.

2001    The XXXIX^th World Congress of Physiological Societies "From Molecule to Maladie" -                              Workshop on K_ATP Channels, Christchurch, New Zealand*.

2001    The XXXIX^th World Congress of Physiological Societies "From Molecule to Maladie" -                              Satellite Symposium "Structure and Function of Ion Channels", Leura, Australia.

2001    The Annual Meeting of The Biophysical Society, Boston, MA.

2000    The Gordon Research Conference on Ion Channels, Tilton School, NH.

2000    The Keystone Meeting on Potassium Channels, Granlibakken, CA.

2000    The Annual Meeting of The Biophysical Society, New Orleans, Lousianna.

1999    The "Ion Channel Structure and Function" Conference in Yale University, New Haven, CT.

1999    The Annual Meeting of The Biophysical Society, Baltimore, MD.

1998    The 2^nd International Conference on ATP-sensitive Potassium Channels and Diseases,                            St. Charles, IL*.

1998    The Gordon Research Conference on Cardiac Regulatory Mechanisms, Colby, NH.

1998    The Gordon Research Conference on Ion Channels, Tilton School, NH.

1998    The XIII^th World Congress of Cardiology, Rio de Janeiro, Brazil.

1998    The Annual Meeting of The Biophysical Society, Kansas City, Missouri.

1997    The Annual Meeting of The Biophjysical Society, New Orleans, Lousiana.

1996    The 20^th Meeting of the European Working Group on Cardiac Cellular Electrophysiology,                        Essen, Germany*.

1996    The XII^th International Biophysics Congress, Amsterdam, The Netherlands*.

1995    The 19^th Meeting of the European Working Group on Cardiac Cellular Electrophysiology                       "Potassium Channels in Normal and Pathological Conditions", Leuven, Belgium*.

1995    The All-Russian Conference "Ionic Homeostasis and Cellular Functions", St. Petersburg,                        Russian Federation*.

1995    The Annual FASEB Meeting, Atlanta, GA.

1994    The ESF Conference on Cardiac Electrophysiology "From the ionic channel to arrhythmia                    mechanisms: Role of potassium channels", Crete*.

1994    The 1^st International Symposium organized by the Problem Commission on General and Cell                Physiology, Russian Academy of Sciences, Leningrad reg., Russian Federation*.

1993    The 1^st International Conference on ATP-sensitive K⁺ Channels and Sulfonylurea Receptors,                Houston, TX.

1993    The All-Russian Conference on Cardiology, St. Petersburg, Russian Federation*.

1992    The 2^nd USSR-USA conference on Ion Channels, a.k.a. "The second Kostyuk - Hille Meeting",               Bogomoletz Institute of Physiology, Kiev, then USSR.

1992    The All-Union Conference "Regulation of Physiological Functions", then Leningrad, USSR*.

REPRESENTATIVE PUBLICATIONS

MANUSCRIPTS IN PEER-REVIEWED JOURNALS (^*THE CORRESPONDING AUTHOR ON ORIGINAL RESEARCH ARTICLES):

Babenko A. P.* Gating and pharmacology of all possible human K_IR6.2_V59X-based channels, including KATP from permanently diabetic subjects with epilepsy and developmental problems. Under re-submission.

Babenko A. P.* and Vaxillaire M. Mechanism of KATP hyperactivity and sulfonylurea tolerance due to a diabetogenic mutation in L0 helix of sulfonylurea receptor 1 (ABCC8). FEBS Letters. 2011. 585: 3555-3559.

Babenko A. P.* A novel ABCC8(SUR1)-dependent mechanism of metabolism-excitation uncoupling. J Biol Chem (Accelerated Publication). 2008. 283: 8788-8782.

 

Babenko A. P*.,  Polak M*.,  Cavé H.,  Busiah K.,  Czernichow P.,  Scharfmann R.,  Bryan J.,  Aguilar-Bryan L., Vaxillaire M., Froguel P. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med. [see Editorial] 2006. 355: 456-466.

 

Babenko A. P. K_ATP channels “vingt ans apres”: ATG to PDB to Mechanism. Journal of Mol Cell Cardiol (Focused Issue K_ATP Channels: From Molecules to disease) 2005. 39: 79-98.

Bryan J., Crane A., Vila-Carriles W., Babenko A. P., Aguilar-Bryan, L.  Insulin secretagogues, sulfonylurea receptors and K_ATP channels. Curr Pharma Design. 2005. 11: 2699-716.

 

Bryan J, Vila-Carriles W. H., Zhao G., Babenko, A. P., Aguilar-Bryan, L. Toward linking structure with function in ATP-sensitive K⁺ channels. Diabetes 2004. 53: S104-S112.

 

Babenko A. P.* and Bryan J. SUR domains that associate with and gate K_ATP pores define a novel gatekeeper. J Biol Chem (cover featured Accelerated Publication). 2003. 278: 41577-41580.

 

Babenko A. P.* and Bryan J. SUR-dependent modulation of K_ATP channels by an N-terminal K_IR6.2 peptide  Defining intersubunit gating interactions. J Biol Chem. 2002. 277: 43997-44004.

 

Babenko A. P.* and Bryan J. A conserved inhibitory and differential stimulatory action of nucleotides on K_IR6.0/SUR complexes is essential for metabolism-excitation coupling by K_ATP channels. J Biol Chem. 2001. 276: 49083-49092.

 

Babenko A. P.*, Gonzalez G., Bryan J. Hetero-concatemeric K_IR6.X₄/SUR1₄ channels display distinct conductivities, but uniform ATP-inhibition. J Biol Chem (Accelerated Publication). 2000. 275: 31563-31566.

 

Babenko A. P.*, Gonzalez G., Bryan J. Pharmaco-topology of sulfonylurea receptors: Separable domains of the regulatory subunits of K_ATP channel isoforms are required for selective interaction with K⁺ channel openers. J Biol Chem (Accelerated Publication). 2000. 275: 717-720.

 

Babenko A. P.*, Gonzalez G., Bryan J. The tolbutamide site of SUR1 and a mechanism for its functional coupling to K_ATP channel closure. FEBS Letters (cover featured). 1999. 459: 367-376.

 

Sharma, N., Crane A., Clement IV J. P., Gonzalez G., Babenko A. P., Bryan J, Aguilar-Bryan L*. The C-terminus of SUR1 is required for trafficking of K_ATP channels. J Biol Chem. 1999. 274: 20628-20632.

 

Babenko A. P.*, Gonzalez G., Bryan J. Two regions of SUR specify the spontaneous bursting and ATP-inhibition of K_ATP channel isoforms. J Biol Chem. 1999. 274: 11587-11592.

 

Babenko A. P.*, Gonzalez G., Aguilar-Bryan L., Bryan J. Sulfonylurea receptors set the maximal open probability, ATP-sensitivity and plasma membrane density of K_ATP channels. FEBS Letters. 1999. 445: 131-136.

 

Babenko A. P.*, Gonzalez G., Bryan J. The N-terminus of K_IR6.2 limits spontaneous bursting and modulates the ATP-inhibition of K_ATP channels. Biochem Biophys Research Communications. 1999. 255: 231-238.

 

Babenko A. P., Aguilar-Bryan L., Bryan J. A view of SUR/K_IR6.X, K_ATP channels. Annu Rev Physiol. 1998. 60: 667-687.

 

Babenko A. P.*, Gonzalez G., Aguilar-Bryan L., Bryan J. Reconstituted human cardiac K_ATP channels: Functional identity with the native channels from the sarcolemma of human ventricular cells. Circ Res. 1998. 83: 1132-1143.

 

Aguilar-Bryan L., Clement IV J. P., Gonzalez G., Kunjilwar K., Babenko A. P., Bryan J. Toward understanding the assembly and structure of K_ATP channels. Physiological Reviews. 1998. 78: 227-245.

 

Babenko A., Vassort G*. Enhancement of the ATP-sensitive K⁺ current by extracellular ATP in rat ventricular myocytes: Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion. Circ Res. 1997. 80: 589-600.

 

Babenko A. P., Vassort G.* Purinergic facilitation of ATP-sensitive potassium current in rat ventricular myocytes. British J Pharmacol. 1997. 120: 631-638.

 

Babenko A. P.*, Kazantseva S. T., Samoilov V. O. Adenosine does not play a fundamental role in activation of K_ATP currents in rat ventricular cardiomyocytes. Biologicheskie Membrany. 1996. 13(1): 19-28.

 

Babenko A. P.*, Vereninov A. A., Glushankova L. N., Romanova Yu. V. Time course of plasma membrane chloride conductance of Jurkat cells during their osmotic swelling. Cytology. 1995. 37(4): 84.

 

Babenko A. P.*, Romanove YU. V. Activity of the single voltage-gated potassium channels in human B lymphocytes analyzed under the conditions of intact intracellular milieu. Uspekhi Fiziologicheskikh Nauk. 1994. 25(1): 46.

 

Babenko A. P.*, Samoilov V. O. Functioning the K⁺ channels opening in ventricular cardiomyocytes sarcolemma upon hypoxia. Biologicheskie membrany. 1994. 11 (1): 35-44.

 

Babenko A. P.*, Samoilov V. O., Kazantseva S. T. Potassium channels in the cardiomyocyte sarcolemma: Initial opening under the influence of hypoxia. Basic and Applied Myology. 1992. 2: 317-324.

 

Babenko A. P.*, Kazantseva S. T., Khavinson V. Kh. Activation of ATP-sensitive K⁺ channels of cardiomyocytes by endogenous cardiopeptides. Bulleteni Exper Biol Med. 1992. 114: 980-984.

 

Babenko A. P.* and Cherniakov G. M. The characteristics of the reactions of excitable tissue to combined exposure to microwaves and low-intensity ultrasound. Gig Tr Prof Zabol. 1992. 5: 19-21.

 

Babenko A. P.*, Samoilov V. O., Kazantseva S. T., Shevchenko Yu. L. ATP-sensitive K⁺-channels in the human adult ventricular cardiomyocytes membrane. FEBS Letters. 1992. 313: 148-150.

 

Babenko A. P.* and Samoilov V. O. The reaction to hypoxia of ATP-sensitive K⁺ channels in rat cardiomyocytes. Fiziol Zh SSSR Im I. M. Sechenova. 1991. 77 (11): 55-59.

Babenko A. P. acknowledges that the first homologous KATP was defined in Naunyn-Schmiedeberg's Archives of Pharmacology, not in Nature, and the Nobel-winning "patch-clamp" method was originally described in another "specialized" German journal, Pflügers Archiv.

Babenko A. P. reminds that the retracted Cloning and functional reconstitution of a rat KATP, as well as the similarly artificial and tenure-facilitating Promiscuity of SUR toward inward rectifiers, were delivered in the strikingly similar British.

Book chapters:

Babenko A. P., Sharma N., Aguilar-Bryan L., Gonzalez G., Bryan J. Coupling between SUR1 and K_IR6.2 specifies properties of b-cell K_ATP channels. pp. 44-60 in Molecular Pathogenesis of MODYs, edited by F. M. Matschinsky and M. A. Magnuson. Frontiers in Diabetes. Vol. 15, Karger, Basel, 2000.

 

Babenko A. P. Testing the adenosine-activatability of the ATP-sensitive potassium (K_ATP) current in neonatal and adult rat ventricular cardiomyocytes. pp. 322-325. In: Potassium channels in normal and pathological conditions, Eds: Vereecke J., van Bogaert P.P. and Verdonck F. Leuven, University Press, Leuven, 1995.

 

Samoilov V. O., Babenko A. P., Kazantseva S. T. Heterogeneity of mechanisms of cardiac potassium channels activation under pathophysiological conditions. pp. 146-156. In: Actual Problems of General Toxicology (In Russian). St. Petersburg. 1995.

 

Babenko A. P., Romanova Yu. V., Babenko I. M., Vereninov A. A. Reaction of ionic permeability of K562 cell plasmalemma on hypotonicity. pp. 21-32. In: Actual Problems of General and Marine Toxicology. MMA, St. Petersburg, 1995.

 

Babenko A. P., Kazantseva S. T., Romanova Yu. V., Samoilov V. O. Molecular mechanisms of ATP-sensitive potassium channels activation in cardiomyocytes sarcolemma during hypoxia. pp. 24-35. In: Ecological and Physiological Problems of Adaptation (In Russian). Moscow, 1994.

 

Cherniakov G. M., Korotchkin V. L., Babenko A. P., Bigdai E. V. Responses of biosystems with different level of integrity to low-intensive UHF ratiation. pp. 140-167 in: Millimeter Waves in Medicine and Biology (In Russian). Moscow, 1989.

Selected abstracts in refereed journals (*THE CORRESPONDING AUTHOR):

Babenko A. P.* and Vaxillaire M. The predominant mechanisms of pathogenic hyperactivity of mutant ABCC8/KCNJ11-coded K_ATP channels. Biophys J. 2011. 96(1) Pt. 2: on-line.

Babenko A. P.* Diabetogenic ABCC8/KCNJ11: Mechanisms to personalized treatment. Basic and Clinical Pharmacology and Toxicology. In press.

Babenko A. P.* How do mutations in M0 of KCNJ11 produce diabetes? Biophys J. 2010. 95(1) Pt. 2: on-line.

Babenko A. P.* How do mutations in the L0-linker of ABCC8 produce neonatal diabetes? Biophys J. 2009. 94(1) Pt. 2: on-line.                                                                        

Babenko A. P.* and Zhao G. Mechanisms of I_KATP hyperactivation by diabetogenic mutations in SUR1. Biophys J. 2007. 92(1) Pt. 2: on-line.                                                                        

 

Babenko A. P.* and Zhao G. K_IR6.2X59 clarify the gating mechanism in intact and DEND K_ATP channels. Biophys J. 2006. 90(1) Pt. 2: on-line.

 

Babenko A. P.* The open time of K_ATP pore logarithms its gatekeepers-dependent burst time via “one way” coupling mechanism. Biophys J. 2005. 88(1) Pt. 2: 177a.

 

Babenko A. P.* and Bryan, J. Mini-K_ATP reveal a novel gatekeeper for long K⁺ pores. Biophys J. 2004. 86(1) Pt. 2: 177a.

 

Babenko A. P.* and Bryan, J. Studies on cloned human KCNJ8: Lessons about K_NDP vs classic, hybrid, and “mitochondrial K_ATP“ channels. Circulation. 2003. On-line.

 

Babenko A. P.* and Bryan, J. TMD0-L0 links the SUR ATP-binding core to the K_ATP pore. FASEB J. 2003. 17: 369.11.

 

Babenko A. P.* and Bryan, J. Kir6.0/SUR interactions stabilizing closed K_ATP channels. Biophys J. 2003. 84(2) Pt. 2: 81A.

 

Babenko A. P.*, Crane A., Vila-Carriles, W., Aguilar-Bryan, L., Bryan, J. Interactions of the 2^nd generation sulfonylureas with K_ATP channels. The Pharmacologist. 2002. 44: A189.

 

Babenko A. P. * and Bryan J. Can heteromultimerization of K_IR6.0 subunits up-regulate K_ATP channel activity in vivo? Biophys J. 2002. 82(1) Pt. 2: 181A.

 

Babenko A. P.* Perturbations of K_IR6.0/SUR questioning the interburst closed state-delimited binding of ATP to K_ATP channels. Biophys J. 2001. 80(1) Pt. 2: 625A.

 

Babenko A. P.* and Bryan J. The ATP-inhibitory gating machinery is conserved in K_ATP, K_NDP, and all possible hybrid K_IR6.0/SUR₄ channels. Biophys J. 2001. 80(1) Pt. 2: 512A.

 

Babenko A. P.* and Bryan J. Functional topology of the regulatory subunits of K_ATP channels. Biophys J. 2000. 78(1) Pt. 2: 463A.

 

Babenko A. P.*, Gonzalez, G., Bryan J. The mechanism of high-affinity sulfonylurea-inhibition of (SUR1/K_IR6.2)₄ channels: Uncovering functional coupling between the regulatory and pore forming subunits in K_ATP channel gating. The Physiologist. 1999. 42(4): A2.

 

Babenko A. P.*, Bryan J. K_IR6.2 and sulfonylurea receptors share determinants of ATP inhibitory gating of K_ATP channels. Biophys J. 1999. 76(2): A14.

 

Babenko A. P.*, Gonzalez, G., Aguilar-Bryan, L., Bryan J. Reconstituted human cardiac ATP-sensitive K⁺ channel: Functional identity with the native channels in human ventricular cells. Journal of The American College of Cardiology. 1998. 31(5); Supplement C: 108C.

 

Babenko A. P.* and Bryan J. What have we learned from C-terminus truncated K_IR6.2 channels? Biophys J. 1998. 74(2): A114.

 

Babenko A. P.* and Vassort G. Agonist-independent, GTP-induced stimulation of cardiac K_ATP channels. Biophys J. 1997. 72(2): A249.

 

Babenko A. P.* and Vassort G. P₂-purinoceptors-mediated enhancement of cardiac ATP-sensitive K⁺ channel (K_ATP) current. Progress in Biophysics and Molecular Biology. 1996. 65(1): 89.

 

Babenko A. P.* and Vassort G. Can cytoskeleton actin stabilization and tyrosine kinase inhibition affect cardiac K_ATP channels run-down and reactivation by MgATP in inside-out membrane fragments?  Biophys J. 1996. 70(2): A398.

 

Babenko A. P.*, Romanova Yu. V., Vereninov A. A., Glushankova L. N.  Time course of plasma membrane chloride conductance  (gCl^-) in Jurkat cells during osmotic swelling at cytoplasm preservation. FASEB Journal. 1995. 9(3): A389.

 

Samoilov V. O., Babenko A. P.*, Kazantseva S. T. Modulation of cardiac glibenclamide-sensitive K⁺ currents during metabolic inhibition: Perforated patch-clamp study. FASEB Journal. 1995. 9(3): A388.

 

Babenko A. P.*, Kazantseva S. T., Samoilov V. O. Adenosine-triphosphate-sensitive potassium channels do not play a fundamental role in adenosine-activated potassium currents in rat and human cardiomyocytes. Drug Dev Res. 1994. 31 (4): P32.

 

Babenko A. P.*, Kazantseva S. T., Samoilov V. O. Does adenosine activate ATP-sensitive potassium currents in neonatal and adult ventricular cardiomyocytes? Cell Biology International. 1994. 18 (5): 404.

Babenko A. P. shared as many as possible of his personal discoveries and turned-to-be-true predictions using as few as possible gigabits of the public storage called pubmed. 

Babenko A. P. never submitted to any Editor looking for anything that will "go viral" to increase the visibility of the publisher.

Babenko A. P. emphasizes that a scientific research paper must deliver new information, that is defined scientifically as the amount of ambiguity eliminated upon receiving the message. Unfortunately, most of nowadays scientific publications are just messages.

LINGUAL PROFICIENCY (BESIDES THAT IN A PROFESSIONAL JARGON-ENRICHED VARIANT OF AMERICAN ENGLISH:)

Russian (родной Mother tongue, the richest and the most powerful of all tongues indeed)

Ukrainian (розумію as Father language, which since the Maidan Coup d'état is used to say nothing good)

Latin (limited to what Graduates of Military Academies and Medical and Law Schools use to be laconic)

Deutsche Sprache (fergessen, entshuldigen sie mir bitte, but restorable in the Germanistic environment)

Millennial Lexicons, including the World-Wide Wordless one, spread mostly by Gen Y single-fingered typists (an entry level skills) and the other one, spread mostly orally by Millennial pop cuties with an Xtremely limited vocabulary (a deeper level skills sufficient to improve some professional voice-over-translations of interviews by super-neo-liberal bilinguals, like the one in the link above that nobody under 18 should listen to).

PERSONALITY, MENTALITY, VIA AND OTHER CHARACTERISTICS THAT INTERVIEWERS SHOULD TAKE INTO ACCOUNT

Predominantly INTJ-type introversive sanguine choleric; conceptually and critically thinking novelty seeker;  perspective individuum who showed valor, perseverance, zest, integrity, loyalty and forgiveness; modestly opportunistic maximalist; agile, "harnessing slowly to run fast"; unapologetically straightforward; brutally honest; gently sarcastic; safely open-minded; traditionally progressive; contra-neo-liberal; conservatively democratic, despising political correctness; hypocricy-intolerant; patriotically anti-xenophobic cosmopolite, opposing unipolar globalism and respecting any developing state industrialism outperforming any imperial monopolism; selectively eclectic; naturally omnivorous, preferring Mediterranean food, unfiltered Cabernet Sauvignon, and Sauterne for dessert if no White Muscat of the Red Stone is available; middle roast Arabica coffee and black Ceylon tea-requiring Early Owl Chronotype, taking no other stimulant; never-and-nothing-smoking; modestly OD nearsighted, while OS presbiopic, not needing any other prescription; opposing drug advertisement on TV, arm sales to masses, and other only-in-America legalized things; aggressively anti-militaristic follower of dual technologies; religiously atheistic and gnostic; PAS-accepting pro-choice proponent, who self-administered the eventually perfected Variola vera vaccine, got immune to almost everything else on the planet, following the wisdom "everything what does not kill a man only makes him stronger", and gave at least 5 litters of his almost universally receivable blood to save several Rh+ who've learned a few things Gruppa Krovi actually tells us. Andrey Petrovich is an old-fashioned, heterosexual, matriarchal masculinist who carries a few high-penetrance irresistible eye-color polymorphisms and shares that view, yet любит безумно только Свою Избранную с безнадежно-печальными карими очами,

Илона Михайловна Бабенко

Ilona Michailovna Babenko,

 

EDUCATION

B.S./M.Sc. in Biology/Human and Animal Physiology - including Physiology of Lab-related species, e.g. Her Sob - from Saint Petersburg State University. Thesis Study: "Transmembrane redistribution of monovalent cations and changes in ion fluxes through plasma membrane of Jurkat and K562 cells under hypotonia" at the Institute of Cytology RAS (Co-Adviser - Professor of Cell Biology A. A. Vereninov), 1994.

                                                                                                                     

RESEARCH POSITIONS AND EXPERIENCE (ANTI-CHRONOLOGICALLY)

Research Scientist III, University of Washington in Seattle UW Diabetes Research Center, conducting Biomedical Research and Managing Laboratory Оperations. 2022-

Research Scientist II, University of Washington in Seattle (UW) Diabetes and Obesity Center of Excellence directed by Professor M. W. Schwartz, MD. Working with multiple PIs conducting federally and non-federally funded projects on Molecular Mechanisms of Metabolic Disorders, including atherosclerosis, one of the commonest diseases, first modeled and investigated by the Nobel Prize in Physiology or Medicine-deserving Medical Scientist, Military Doctor and State Activist, Academician Nikolay Nikolaevich Anichkov, the Full Professor of her husband's Alma Mater and the Honorary Professor of other World's top Academies and Universities. 2008-22

Research Scientist 2, The UW Department of Medicine, Division of Metabolism, Endocrinology and Nutrition. Mastered in mass spectrometry under the supervision of Dr. T. Vaisar, Ph.D., at the UW Medicine Mass Spectrometry Resource, directed by Professor J. W. Heinecke, M.D., and applied proteomics techniques and  methods of molecular cell biology while working on two NIH-funded basic and translational research projects dealing with apoA-I lipoprotein in the pathogenesis of atherosclerosis. 2007-8.

Research Assistant II, Section of Cellular Oncology (Chief - Professor W. N. Hittelman, M.D.), Department of Experimental Therapeutics, Division of Medicine, The University of Texas M. D. Anderson Cancer Center (UT MDACC), Houston. Studied Cyclin D1 (CD1) polymorphisms in Barrett’s esophagus/adenocarcinoma. Analyzed CD1 gene amplification in biopsy samples. Developed ecdysone-inducible expression system for CD1 in MCK cells. Tested whether cortactin is a predictor of aggressive phenotype in head and neck cancer. Compared gastrin secretion from different esophageal tumor cell lines using ELISA. Analyzed the hedgehog pathway in esophageal tumor cell lines and effects of bile acids on the hedgehog signaling. Examined Gli-1 and nf-kb activity in anal cancer. 2001-7.

Research Assistant I, Section of Cellular Oncology, Department of Experimental Therapeutics, Division of Medicine, UT MDACC. Optimized ecdysone-inducible expression system for CD1 in WI38SV40 cells. Under Dr. J. G. Izzo, Ph.D., supervision, correlated CD1 polymorphisms and risk of cancer development in the upper aerodigestive tract. 1999–2001.

Research Assistant at the INSERM Unit of Cardiovascular Physiopathology in Montpellier, then directed by Dr. G. Vassort, D.Sc., and Junior Researcher in the Saint Petersburg State Medical University Molecular Cardiology Group, then led by Dr. A. P. Babenko, M.D., Ph.D. Assisted PIs in conducting their International Collaborative Research Projects funded by the National Institute of Health and Medical Research and RFBR. Assisted Dr. M. Puceat, D.Sc., later Director of INSERM Program on Physiopathology of Cardiac Development, in preparing the primary culture of neonatal rat cardiocytes for viral gene transfer, microinjections and electrophysiological studies conducted by Her Beloved, a Visiting Scientist at INSERM, heading his own Lab at SPbGMU, Dr. A. P. Babenko, M.D. Ph.D. The engagement in France was a part-time job, so the young mom was able to fully enjoy life while caring for their petite fille "Kotya" sur la Côte d'Azur . 1995-6.

Research Assistant (part-time to take care of the little Tamara) at the Institute of Cytology RAS National Cell Line Collection, then directed by the President of the European Tissue Culture Society - Russian Branch, Professor of Cell Biology G. P. Pinaev, D.Sc. Cultured various cell types without antibiotic and conducted mycoplasma testing and cytotoxicity studies. Under supervision of Dr. G. G. Poljanskaya, PhD, karyotyped cell lines derived from solid tumors. Using videomicroscopy, spectro-photometry and ion-flux assay, clarified ionic mechanisms of the regulatory volume decrease in lymphoid and myelogenous cell lines, 1994-5.

LABORATORY TECHNIQUES AND SKILLS

Proteomics techniques: mass-spectrometry, including ESI and MALDI TOF/Quadrupole MS; Tandem MS; HPLC.

Cell biology techniques: tissue culture, including primary culture of freshly isolated mammalian cardiocytes and human lymphocytes; establishing stable cell lines; determining the growth curve; micromanipulation; Nomarski and fluorescence confocal microscopy; tumor cell invasion (Boyden chamber) and wound healing assays.

Molecular biology and biochemistry techniques: DNA and RNA extraction and electrophoresis; DNA sequencing; single strand conformational polymorphism analysis; PCR, RT-PCR, and Quantitative Real Time PCR; molecular cloning; restriction enzyme digestion and agarose gel analysis; preparation of expression vectors; mini and maxi preparation of cDNA plasmids; Northern and Southern blot; in situ hybridization; siRNA; transfection; immunoprecipitation; protein expression and purification; SDS-PAGE, Western blot.

Immunological methods: immunocytochemistry, immunofluorescence staining, ELISA.

 

Radioisotope techniques utilizing ³²P labeling, scintillation/gamma counting.

Working with human subjects, including blood samples processing and microdissection of biopsy specimens.

Basic veterinary skills, including simple surgery on rodents.

General laboratory skills, including buffer preparation, sterilization, centrifugation, photo-documenting, record keeping, organizing databases, record keeping, etc.

  

SOFT SKILLS

Microsoft Office, ISI ResearchSoft EndNote, Scanning & OCR Software, Jask Paint Shop Pro Soft, Adobe Acrobat, Illustrator, and other Creative Suit Software Tools.

Advanced image analysis software, including MetaMorph Image Analysis (just basic procedures).

Statistical analysis tools, including Splus 45, SPSS, and Microcal Origin Software (basic procedures only).

 

 

EXPERIENCE IN LAB MANAGEMENT

Maintained records of cell lines and molecular reagents since 1994.

Monitored work flow of laboratory supplies and proper functioning of laboratory equipment since 1994. 

Placed and followed up Repair and Purchase Orders since 2001.

Performed monthly wipe tests and prepared quarterly radiation safety reports for over four years after taking

 a course in Safe Handling of Radioactive Materials in Research and Clinical Laboratories in 2002.

Troubleshooted and optimized PCR, Western blot, immunostaining, and other cell biology assays since 2002.

Supervised three Research Assistants and trained more than ten PhD students in tissue culture, Western blotting and other basic laboratory techniques since 2003.

Assisted PIs in collection and preparation of data for grant applications, manuscripts, and scientific presentations since 2003.